Fatigue (persistent fatigue, exhaustion and listlessness) severely impairs patient quality of life but is still one of the most difficult MS symptoms to treat (Sumowski 2014); the difficulty in detecting fatigue up to now exacerbates the problem. Recent research results allow more effective diagnosis towards developing therapeutic approaches, such as targeted administration of medicines to lower core body temperature and alleviate or prevent an imminent bout of fatigue. This requires continuous core body temperature monitoring and individual temperature pattern analysis.

Relapses are currently detected too late for medical intervention. It is safe to assume that core body temperature indicates an atypical and specific clinical course before or during a relapse. This particular disease seems to be connected to the menstrual cycle (Sekigawa 2010), warranting special interest in measuring core body temperature as it reflects all the endocrinological processes in the body. Specifically, deterioration in systemic lupus erythematosus symptoms has been observed in the premenstrual phase, early pregnancy and the postpartum period (Sekigawa 2010 and Yell 2006). Several studies have shown oestrogen to increase the extent and severity of systemic lupus erythematosus in women and experimental animals (Khan 2016). This phenomenon strongly suggests a close relationship between increased oestrogen levels and relapses (Sekigawa 2010).

Body-core temperature changes recorded in lupus patients may indicate an immunological reaction; if so, this would make a substantial contribution to further research in systemic lupus erythematosus and point the way to new research approaches. Body core temperature should be used as a biomarker especially in early diagnosis of relapses in autoimmune disease, as this would allow individualized diagnosis and treatment matched for each patient.